PBRM1-BD2-IN-2

PBRM1-BD2-IN-2 is a selective and cell-active polybromo-1 (PBRM1) bromodomain inhibitor. PBRM1-BD2-IN-2 has binding affinity and inhibitory activity for PBRM1-BD2 with Kd and IC50 values of 9.3 μM and 1.0 μM, respectively. PBRM1-BD2-IN-2 can be used for the research of cancer[1].

Product Specifications

CAS Number

[2819989-57-4]

UNSPSC

12352005

Target

Epigenetic Reader Domain

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pbrm1-bd2-in-2.html

Purity

99.0

Solubility

DMSO : 45 mg/mL (ultrasonic; warming)

Smiles

O=C1NC(C2=C(F)C=CC=C2Cl)NC3=C1C(Cl)=CC=C3

Molecular Formula

C14H9Cl2FN2O

Molecular Weight

311.14

References & Citations

[1]Shifali Shishodia, et al. Selective and Cell-Active PBRM1 Bromodomain Inhibitors Discovered through NMR Fragment Screening. J Med Chem. 2022 Oct 13.