CypE-IN-1

CypE-IN-1 is a potent and subtype-selective cyclophilin E (CypE) inhibitor. CypE-IN-1 has CypE affinity with IC50 and Ki values of 0.013 μM and 0.072 μM, respectively. CypE-IN-1 can be used for the research of several diseases including oxidative stress, neurodegenerative disorders, liver diseases, aging, autophagy and diabetes[1].

Product Specifications

CAS Number

[3023438-33-4]

UNSPSC

12352005

Target

Cyclophilin

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cype-in-1.html

Solubility

10 mM in DMSO

Smiles

[H]C(C1=C(C=C(C=C1)C2=CC=C(C=C2)C[C@@H]3NC([C@@]4(CCCN(C(/C=C/C(NCC[C@H](NC(CC5=C(CNC3=O)C=CC=C5)=O)C(N)=O)=O)=O)C4)CC6=CC=CC=C6)=O)B(O)O)=O

Molecular Formula

C46H49BN6O9

Molecular Weight

840.73

References & Citations

[1]Alexander A Peterson, et al. Discovery and molecular basis of subtype-selective cyclophilin inhibitors. Nat Chem Biol. 2022 Sep 26.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Cyclophilin A; Cyclophilin B; Cyclophilin C; Cyclophilin D; Cyclophilin E; Cyclophilin G

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