CypE-IN-1
CypE-IN-1 is a potent and subtype-selective cyclophilin E (CypE) inhibitor. CypE-IN-1 has CypE affinity with IC50 and Ki values of 0.013 μM and 0.072 μM, respectively. CypE-IN-1 can be used for the research of several diseases including oxidative stress, neurodegenerative disorders, liver diseases, aging, autophagy and diabetes[1].
Product Specifications
CAS Number
[3023438-33-4]
UNSPSC
12352005
Target
Cyclophilin
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cype-in-1.html
Solubility
10 mM in DMSO
Smiles
[H]C(C1=C(C=C(C=C1)C2=CC=C(C=C2)C[C@@H]3NC([C@@]4(CCCN(C(/C=C/C(NCC[C@H](NC(CC5=C(CNC3=O)C=CC=C5)=O)C(N)=O)=O)=O)C4)CC6=CC=CC=C6)=O)B(O)O)=O
Molecular Formula
C46H49BN6O9
Molecular Weight
840.73
References & Citations
[1]Alexander A Peterson, et al. Discovery and molecular basis of subtype-selective cyclophilin inhibitors. Nat Chem Biol. 2022 Sep 26.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cyclophilin A; Cyclophilin B; Cyclophilin C; Cyclophilin D; Cyclophilin E; Cyclophilin G
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