CypD-IN-4
CypD-IN-4 is a potent and subtype-selective cyclophilin D (CypD) inhibitor. CypD-IN-4 has CypD affinity with an IC50 value of 0.057 μM. CypD-IN-4 can be used for the research of several diseases including oxidative stress, neurodegenerative disorders, liver diseases, aging, autophagy and diabetes[1].
Product Specifications
CAS Number
[3023438-19-6]
UNSPSC
12352005
Target
Cyclophilin
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cypd-in-4.html
Solubility
10 mM in DMSO
Smiles
NCCOCCNC([C@@H]1CCNC(/C=C/C(N2CCC[C@](C2)(C(N[C@H](C(NCC3=C(CC(N1)=O)C=CC=C3)=O)CC4=CC=C(C=C4)C5=CC=C(C=C5)C(CC(O)=O)CC(O)=O)=O)CC6=CC=CC=C6)=O)=O)=O
Molecular Formula
C54H63N7O11
Molecular Weight
986.12
References & Citations
[1]Alexander A Peterson, et al. Discovery and molecular basis of subtype-selective cyclophilin inhibitors. Nat Chem Biol. 2022 Sep 26.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cyclophilin A; Cyclophilin B; Cyclophilin D; Cyclophilin E
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