GID4 Ligand 1

GID4 Ligand 1 (compound 88) is a cell-permeable and high-selective GID4 binder (IC50=5.4 μM; Kd=5.6 μM), binds to GID4 in cells (EC50=558 nM) . GID4 Ligand 1 can be used for the synthesis of PROTACs[1].

Product Specifications

CAS Number

[3031442-96-0]

UNSPSC

12352005

Target

Ligands for Target Protein for PROTAC

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/gid4-ligand-1.html

Solubility

10 mM in DMSO

Smiles

O=C(NC)[C@@H](NC([C@H](NC(CNCC1=CC=C(OC)C=C1OC)=O)C2=CC=CS2)=O)CCC3=CC=CC=C3

Molecular Formula

C28H34N4O5S

Molecular Weight

538.66

References & Citations

[1]Chana CK, et al. Discovery and Structural Characterization of Small Molecule Binders of the Human CTLH E3 Ligase Subunit GID4. J Med Chem. 2022 Sep 18.