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HCAIX/XII-IN-6

HCAIX/XII-IN-6 is an orally active carbonic anhydrase (CA) inhibitor. hCAIX/XII-IN-6 inhibits human CA isoforms hCA I, II, IV, IX, and XII with Ki values of 6697 nM, 2950 nM, 4093 nM, 4.1 nM and 7.7 nM, respectively. hCAIX/XII-IN-6 can be used for the research of rheumatoid arthritis (RA) [1].

Product Specifications

CAS Number

3031666-31-3

UNSPSC

12352005

Target

Carbonic Anhydrase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/hcaix-xii-in-6.html

Solubility

10 mM in DMSO

Smiles

O=C(N(CC1=CC=C([N+]([O-])=O)C=C1OC)CCC2=CC=C(S(=O)(N)=O)C=C2)C3=CC=C(C4=CSSC4=S)C=C3

Molecular Formula

C26H23N3O6S4

Molecular Weight

601.74

References & Citations

[1]Alessandro Bonardi, et al. Development of Hydrogen Sulfide-Releasing Carbonic Anhydrases IX- and XII-Selective Inhibitors with Enhanced Antihyperalgesic Action in a Rat Model of Arthritis. J Med Chem. 2022 Sep 19.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CA II; CA IX; CA XII

Frequently Asked Questions

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