SHP2/HDAC-IN-1

SHP2/HDAC-IN-1 is a dual allosteric SHP2/HDAC inhibitor with IC50 values of 20.4 nM (SHP2) and 25.3 nM (HDAC1) respectively. SHP2/HDAC-IN-1 triggers efficient antitumor immunity by activating T cells, enhancing the antigen presentation function and promoting cytokine secretion. SHP2/HDAC-IN-1 can be used in the research of cancer immunoresearch[1].

Product Specifications

CAS Number

[2831230-38-5]

UNSPSC

12352005

Target

HDAC; Phosphatase; SHP2

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK

Applications

COVID-19-anti-virus

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/shp2-hdac-in-1.html

Solubility

10 mM in DMSO

Smiles

O=C(NCC1=CC=C(/C=C/C(NO)=O)C=C1)C2=CC=C(CNC3(C)CCN(C4=NC(N)=C(C5=C(Cl)C(Cl)=CC=C5)N=C4)CC3)C=C2

Molecular Formula

C34H35Cl2N7O3

Molecular Weight

660.59

References & Citations

[1]Meng Liu, et al. Discovery of Novel Src Homology-2 Domain-Containing Phosphatase 2 and Histone Deacetylase Dual Inhibitors with Potent Antitumor Efficacy and Enhanced Antitumor Immunity. J Med Chem. 2022 Sep 22;65 (18) :12200-12218.