VEGFR-2/DHFR-IN-2
VEGFR-2/DHFR-IN-2 (compound 5b) is an inhibitor of VEGFR-2 and DHFR with IC50s of 0.623 and 9.085 μM, respectively. VEGFR-2/DHFR-IN-2 exhibits good cytotoxic activities against C26, HepG2, and MCF7 cancer cell lines with IC50 values of 3.59-8.38 μM. VEGFR-2/DHFR-IN-2 can be used for the research of cancer[1].
Product Specifications
CAS Number
2831498-09-8
UNSPSC
12352005
Target
Bacterial; Dihydrofolate reductase (DHFR) ; Fungal; VEGFR
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/vegfr-2-dhfr-in-2.html
Solubility
10 mM in DMSO
Smiles
O=C(NCC1=CC=C(C)C=C1)C2=CC(O)=C3C(OC)=CC(OC)=CC3=C2
Molecular Formula
C21H21NO4
Molecular Weight
351.40
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
VEGFR2/KDR/Flk-1
Frequently Asked Questions
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