VEGFR-2/DHFR-IN-1

VEGFR-2/DHFR-IN-1 (compound 8b) is an inhibitor of VEGFR-2 and DHFR with IC50s of 0.384 and 7.881 μM, respectively. VEGFR-2/DHFR-IN-1 shows good antibacterial activities against Escherichia coli, Streptococcus faecalis, Salmonella enterica, MSSA and MRSA with MIC values of 16, 16, 16, 8, and 16 μg/mL, respectively. VEGFR-2/DHFR-IN-1 exhibits good cytotoxic activities against C26, HepG2, and MCF7 cancer cell lines with IC50 values of 2.97-7.12 μM. VEGFR-2/DHFR-IN-1 can be used for the research of cancer[1].

Product Specifications

CAS Number

[2831498-15-6]

UNSPSC

12352005

Target

Bacterial; Dihydrofolate reductase (DHFR) ; Fungal; VEGFR

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/vegfr-2-dhfr-in-1.html

Solubility

10 mM in DMSO

Smiles

O=C(NCC1=CC=C(Cl)C=C1)C2=CC(O)=C3C(OC)=CC(OC)=CC3=C2

Molecular Formula

C20H18ClNO4

Molecular Weight

371.81

References & Citations

[1]Pham EC, et al. Design, Microwave-Assisted Synthesis, Antimicrobial and Anticancer Evaluation, and In Silico Studies of Some 2-Naphthamide Derivatives as DHFR and VEGFR-2 Inhibitors. ACS. 2022.