Topoisomerase IIα-IN-4

Topoisomerase IIα-IN-4 (F2) is a non-intercalative ATP-competitive human DNA topoisomerase II inhibitor with an IC50 value of 3.8 and 10.1 μM for TopoIIα and TopoIIβ, respectively. Topoisomerase IIα-IN-4 shows potent potency in apoptosis induction and cell cycle arrest in HepG2 cells. Topoisomerase IIα-IN-4 exhibits strong antitumor activities against human cancer cell lines, it can be used for the research of cancer[1].

Product Specifications

CAS Number

[2860554-26-1]

UNSPSC

12352005

Target

Apoptosis; Topoisomerase

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/topoisomerase-iiα-in-4.html

Solubility

10 mM in DMSO

Smiles

O=C(NC1=CC=C(C2=CC=C3C=C(O)C=CC3=C2)C=C1)CCC4=CC=CC=C4

Molecular Formula

C25H21NO2

Molecular Weight

367.44

References & Citations

[1]Xu G, et al. Discovery of 1,2-diphenylethene derivatives as human DNA topoisomerase II catalytic inhibitors and antitumor agents. Eur J Med Chem. 2022 Aug 26;243:114706.