Cav 3.2 inhibitor 3
Cav 3.2 inhibitor 3 (Compound 4) is a potent Cav3.2 T-type Ca2+ channel inhibitor with an IC50 of 0.1534 μM, and has little binding affinity to D2 receptors[1].
Product Specifications
CAS Number
2878598-69-5
UNSPSC
12352005
Target
Calcium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cav-3-2-inhibitor-3.html
Solubility
10 mM in DMSO
Smiles
O=C1N(C2CCN(C(CCCC3=CC=CC=C3)=O)CC2)C4=CC=CC=C4N1CCCCC5=CC=CC=C5
Molecular Formula
C32H37N3O2
Molecular Weight
495.66
References & Citations
[1]Kasanami Y, et al. Discovery of pimozide derivatives as novel T-type calcium channel inhibitors with little binding affinity to dopamine D2 receptors for treatment of somatic and visceral pain. Eur J Med Chem. 2022 Aug 27;243:114716.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
T-type calcium channel
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