(S) -Trichostatin A
(S) -Trichostatin A ((S) -TSA) is a HDAC6-selective inhibitor with IC50s of 9.88 nM and 11.1 nM for Zebrafish HDAC6 and Human HDAC6, respectively. (S) -Trichostatin A weakly inhibits other human HDACs[1].
Product Specifications
CAS Number
[122292-85-7]
Product Name Alternative
(S) -TSA
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/s-trichostatin-a.html
Solubility
10 mM in DMSO
Smiles
ONC(/C=C/C(C)=C/[C@H](C)C(C1=CC=C(C=C1)N(C)C)=O)=O
Molecular Formula
C17H22N2O3
Molecular Weight
302.37
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Yasuyuki Miyake, et al. Structural insights into HDAC6 tubulin deacetylation and its selective inhibition. Nat Chem Biol. 2016 Sep;12 (9) :748-54.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC10; HDAC11; HDAC2; HDAC3; HDAC4; HDAC5; HDAC6; HDAC7; HDAC8; HDAC9
Available Sizes
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