LRRK2-IN-5

LRRK2-IN-5 (compound 25) is a potent, orally active, selective leucine rich repeat protein kinase 2 gene (LRRK2) inhibitor with IC50 values of 1.2 and 16 μM for GS LRRK2 and WT LRRK2, respectively. LRRK2-IN-5 inhibits LRRK2 Ser1292 and Ser925 autophosphorylation. LRRK2-IN-5 can cross the blood-brain barrier[1].

Product Specifications

CAS Number

[2892451-45-3]

UNSPSC

12352005

Target

LRRK2

Type

Reference compound

Related Pathways

Autophagy

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/lrrk2-in-5.html

Solubility

10 mM in DMSO

Smiles

CC1=NC=CC(C2=NNC(C)=C2C3=CC(F)=C(C(F)=C3)N4CCC5(C4)CCS(=O)(CC5)=O)=C1

Molecular Formula

C24H26F2N4O2S

Molecular Weight

472.55

References & Citations

[1]Leśniak RK, et, al. Discovery of azaspirocyclic 1H-3,4,5-Trisubstitued pyrazoles as novel G2019S-LRRK2 selective kinase inhibitors. Eur J Med Chem. 2022 Nov 15;242:114693.