GLS1 Inhibitor-6
Product Specifications
UNSPSC Description
GLS1 Inhibitor-6 (Compound 24y) is an orally active, potent and selective glutaminase 1 (GLS1) inhibitor (IC50=68 nM), shows 220-fold selectivity for GLS2. GLS1 Inhibitor-6 shows good anti-tumor activity, antitumor cell proliferation activity and induces apoptosis[1].
Target Antigen
Apoptosis; Glutaminase
Type
Reference compound
Related Pathways
Apoptosis;Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gls1-inhibitor-6.html
Solubility
10 mM in DMSO
Smiles
O=C(NCC1CCN(CCCCCC)CC1)C2=CC=CC(COCCC3CCN(C4=NN=C(NC(CC5=CC=CC=C5)=O)S4)CC3)=C2
Molecular Weight
660.91
References & Citations
[1]Tao Yang, et al. Design, synthesis, and pharmacological evaluation of 2-(1-(1,3,4-thiadiazol-2-yl)piperidin-4-yl)ethan-1-ol analogs as novel glutaminase 1 inhibitors. Eur J Med Chem. 2022 Aug 19;243:114686.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-151434/GLS1-Inhibitor-6-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-151434/
Clinical Information
No Development Reported
CAS Number
3033615-55-0
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