GLS1 Inhibitor-6

GLS1 Inhibitor-6 (Compound 24y) is an orally active, potent and selective glutaminase 1 (GLS1) inhibitor (IC50=68 nM), shows 220-fold selectivity for GLS2. GLS1 Inhibitor-6 shows good anti-tumor activity, antitumor cell proliferation activity and induces apoptosis[1].

Product Specifications

CAS Number

[3033615-55-0]

UNSPSC

12352005

Target

Apoptosis; Glutaminase

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/gls1-inhibitor-6.html

Solubility

10 mM in DMSO

Smiles

O=C(NCC1CCN(CCCCCC)CC1)C2=CC=CC(COCCC3CCN(C4=NN=C(NC(CC5=CC=CC=C5)=O)S4)CC3)=C2

Molecular Formula

C37H52N6O3S

Molecular Weight

660.91

References & Citations

[1]Tao Yang, et al. Design, synthesis, and pharmacological evaluation of 2- (1- (1,3,4-thiadiazol-2-yl) piperidin-4-yl) ethan-1-ol analogs as novel glutaminase 1 inhibitors. Eur J Med Chem. 2022 Aug 19;243:114686.