Antitumor agent-77

Antitumor agent-77 is an antitumor agent, inhibits cancer cells growth and migration. Antitumor agent-77 triggers ferroptosis by inhibiting GPx-4 and elevating COX2. Antitumor agent-77 also activates intrinsic apoptotic pathway (Bax-Bcl-2-caspase-3) and hinders Epithelial-mesenchymal transition (EMT) process of cancer cells[1].

Product Specifications

CAS Number

[2870703-21-0]

UNSPSC

12352005

Target

Apoptosis; Bcl-2 Family; COX; Ferroptosis

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/antitumor-agent-77.html

Solubility

10 mM in DMSO

Smiles

O=C1[O-][Pt+2]([NH3])([NH3])[O-]C(C12CC(C2)(C(F)(F)F)O)=O

Molecular Formula

C7H11F3N2O5Pt

Molecular Weight

455.25

References & Citations

[1]Liu F, et al. Design and biological features of platinum (II) complexes with 3-hydroxy-3- (Trifluoromethyl) cyclobutane-1,1-Dicarboxylate as a leaving ligand. Eur J Med Chem. 2022 Nov 15;242:114673.