Tubulin polymerization-IN-37

Tubulin polymerization-IN-37 is a tubulin polymerization inhibitor (IC50: 2.3 μΜ) . Tubulin polymerization-IN-37 binds to the colchicine site of tubulin and inhibits colchicine binding. Tubulin polymerization-IN-37 can be used in the research of cancers, such as lymphomas[1].

Product Specifications

CAS Number

[2011784-92-0]

UNSPSC

12352005

Target

Microtubule/Tubulin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tubulin-polymerization-in-37.html

Solubility

10 mM in DMSO

Smiles

COC1=CC(CN2C=C3CCC4=C(C3=C2)ON=C4)=CC(OC)=C1OC

Molecular Formula

C19H20N2O4

Molecular Weight

340.37

References & Citations

[1]Michael D Wendt, et al. Development of [1,2]oxazoloisoindoles tubulin polymerization inhibitors: Further chemical modifications and potential therapeutic effects against lymphomas. J Med Chem. 2006 Feb; 49 (3) : 1165-81.