Tubulin polymerization-IN-36
Product Specifications
UNSPSC Description
Tubulin polymerization-IN-36 is a tubulin polymerization inhibitor (IC50: 2.8 μΜ). Tubulin polymerization-IN-36 binds to the colchicine site of tubulin and inhibits colchicine binding. Tubulin polymerization-IN-36 can be used in the research of cancers, such as lymphomas[1].
Target Antigen
Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tubulin-polymerization-in-36.html
Solubility
10 mM in DMSO
Smiles
COC1=CC(CN2C=C3CCC4=C(C3=C2)ON=C4)=CC(OC)=C1
Molecular Weight
310.35
References & Citations
[1]Michael D Wendt, et al. Development of [1,2]oxazoloisoindoles tubulin polymerization inhibitors: Further chemical modifications and potential therapeutic effects against lymphomas. J Med Chem. 2006 Feb; 49(3): 1165-81.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-151397/Tubulin-polymerization-IN-36-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-151397/
Clinical Information
No Development Reported
CAS Number
2011784-91-9
Curated Selection
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