Tubulin polymerization-IN-36

Tubulin polymerization-IN-36 is a tubulin polymerization inhibitor (IC50: 2.8 μΜ) . Tubulin polymerization-IN-36 binds to the colchicine site of tubulin and inhibits colchicine binding. Tubulin polymerization-IN-36 can be used in the research of cancers, such as lymphomas[1].

Product Specifications

CAS Number

[2011784-91-9]

UNSPSC

12352005

Target

Microtubule/Tubulin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tubulin-polymerization-in-36.html

Solubility

10 mM in DMSO

Smiles

COC1=CC(CN2C=C3CCC4=C(C3=C2)ON=C4)=CC(OC)=C1

Molecular Formula

C18H18N2O3

Molecular Weight

310.35

References & Citations

[1]Michael D Wendt, et al. Development of [1,2]oxazoloisoindoles tubulin polymerization inhibitors: Further chemical modifications and potential therapeutic effects against lymphomas. J Med Chem. 2006 Feb; 49 (3) : 1165-81.