HDHODH-IN-10
HDHODH-IN-10 is a selective, potent and orally active hDHODH inhibitor, with an IC50 value of 10.9 nM. hDHODH-IN-10 forms hydrogen bonds with key residues Arg136 and Gln47. hDHODH-IN-10 inhibits the proliferation of cancer cells. hDHODH-IN-10 can be used in the research of cancers, such as AML, colorectal cancer[1].
Product Specifications
CAS Number
[3033087-05-4]
UNSPSC
12352005
Target
Dihydroorotate Dehydrogenase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hdhodh-in-10.html
Solubility
10 mM in DMSO
Smiles
C/C(O)=C(C(NC1=C(C=C(C(O[C@H](C(F)(F)F)C)=C1)C(C2=C(C=CC=C2)Cl)=O)F)=O)\C#N
Molecular Formula
C21H15ClF4N2O4
Molecular Weight
470.80
References & Citations
[1]Chungen Li, et al. Discovery of potent human dihydroorotate dehydrogenase inhibitors based on a benzophenone scaffold. European Journal of Medicinal Chemistry, 2022, 243 (5), 114737.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
039055-APC 200 µL
NOP16, CT (NOP16, Nucleolar protein 16, HBV pre-S2 trans-regulated protein 3) (APC) discontinued
Ask
View Details MBS1323881-01 0.05 mg (E-Coli)
Recombinant Chromobacterium violaceum Peptide deformylase (def)
Ask
View Details 
MBS1323881-02 0.05 mg (Yeast)
Recombinant Chromobacterium violaceum Peptide deformylase (def)
Ask
View Details 
MBS1323881-03 0.2 mg (E-Coli)
Recombinant Chromobacterium violaceum Peptide deformylase (def)
Ask
View Details MBS1323881-04 0.5 mg (E-Coli)
Recombinant Chromobacterium violaceum Peptide deformylase (def)
Ask
View Details MBS1323881-05 0.05 mg (Baculovirus)
Recombinant Chromobacterium violaceum Peptide deformylase (def)
Ask
View Details