HDHODH-IN-10

HDHODH-IN-10 is a selective, potent and orally active hDHODH inhibitor, with an IC50 value of 10.9 nM. hDHODH-IN-10 forms hydrogen bonds with key residues Arg136 and Gln47. hDHODH-IN-10 inhibits the proliferation of cancer cells. hDHODH-IN-10 can be used in the research of cancers, such as AML, colorectal cancer[1].

Product Specifications

CAS Number

[3033087-05-4]

UNSPSC

12352005

Target

Dihydroorotate Dehydrogenase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hdhodh-in-10.html

Solubility

10 mM in DMSO

Smiles

C/C(O)=C(C(NC1=C(C=C(C(O[C@H](C(F)(F)F)C)=C1)C(C2=C(C=CC=C2)Cl)=O)F)=O)\C#N

Molecular Formula

C21H15ClF4N2O4

Molecular Weight

470.80

References & Citations

[1]Chungen Li, et al. Discovery of potent human dihydroorotate dehydrogenase inhibitors based on a benzophenone scaffold. European Journal of Medicinal Chemistry, 2022, 243 (5), 114737.