HDAC8/BRPF1-IN-1
Product Specifications
UNSPSC Description
HDAC8/BRPF1-IN-1 (Compound 23a) is a dual inhibitor of HDAC8 and BRPF1 with an IC50 of 443 nM against human HDAC8 and a Kd of 67 nM against human BRPF1. HDAC8/BRPF1-IN-1 shows low in vitro activity against HDAC1 and 6[1].
Target Antigen
Epigenetic Reader Domain; HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hdac8-brpf1-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C(NO)C1=CC=C(OC)C(S(=O)(NC2=CC3=C(N(C)C(C(C)=C3)=O)C=C2)=O)=C1
Molecular Weight
417.44
References & Citations
[1]Ghazy E, et al. Design, synthesis, and biological evaluation of dual targeting inhibitors of histone deacetylase 6/8 and bromodomain BRPF1. Eur J Med Chem. 2020 Aug 15;200:112338.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-151366/HDAC8-BRPF1-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-151366/
Clinical Information
No Development Reported
CAS Number
2484255-85-6
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