HDAC6/8/BRPF1-IN-1

HDAC6/8/BRPF1-IN-1 is a dual inhibitor of both HDAC6/8 and the bromodomain and PHD finger containing protein 1 (BRPF1) . HDAC6/8/BRPF1-IN-1 has inhibitory activity for HDAC1, HDAC6 and HDAC8 with IC50 values of 797 nM, 344 nM and 908 nM, respectively. HDAC6/8/BRPF1-IN-1 has inhibitory activity for BRPF1 with an Kd value of 175.2 nM. HDAC6/8/BRPF1-IN-1 can be used for the research of cancer[1].

Product Specifications

CAS Number

[2484255-65-2]

UNSPSC

12352005

Target

HDAC

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hdac6-8-brpf1-in-1.html

Solubility

10 mM in DMSO

Smiles

O=C(NO)C1=CC=C(S(=O)(NC2=CC3=C(N(C)C(C(C)=C3)=O)C=C2)=O)C=C1

Molecular Formula

C18H17N3O5S

Molecular Weight

387.41

References & Citations

[1]Ehab Ghazy, et al. Design, synthesis, and biological evaluation of dual targeting inhibitors of histone deacetylase 6/8 and bromodomain BRPF1. Eur J Med Chem. 2020 Aug 15;200:112338.