BACE1-IN-11
BACE1-IN-11 is a BACE1 inhibitor. BACE1-IN-11 has the BACE1 inhibitory activity with an IC50 value of 72 μM. BACE1-IN-11 can be used for the research of Alzheimer’s disease (AD) [1].
Product Specifications
CAS Number
1803952-77-3
UNSPSC
12352005
Target
Beta-secretase
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bace1-in-11.html
Solubility
10 mM in DMSO
Smiles
CCC[C@@H](C(O)=O)NC[C@H]([C@@H](NC([C@@H](NC([C@H]([C@H](CC)C)NC([C@H](CCC(O)=O)N)=O)=O)CC1=CC=CS1)=O)CC(C)C)O
Molecular Formula
C30H51N5O8S
Molecular Weight
641.82
References & Citations
[1]Takuya Otani, et al. Macrocyclic BACE1 inhibitors with hydrophobic cross-linked structures: Optimization of ring size and ring structure. Bioorg Med Chem. 2021 Dec 15;52:116517.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BACE1
Frequently Asked Questions
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