HIF-1/2α-IN-1
HIF-1/2α-IN-1 is an orally active HIF-2α inhibitor. HIF-1/2α-IN-1 inhibits HIF-2α activity with an IC50 value of 0.92 μM. HIF-1/2α-IN-1 also can decrease HIF-1α levels. HIF-1/2α-IN-1 can be used for the research of clear cell renal cell carcinoma (ccRCC) [1].
Product Specifications
CAS Number
2827693-99-0
UNSPSC
12352005
Target
HIF/HIF Prolyl-Hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hif-1-2α-in-1.html
Solubility
10 mM in DMSO
Smiles
COC1=CC=C(C=C1OC)C2=NN=C(O2)NC3=NC4=C(N3)C=CN=C4OC
Molecular Formula
C17H16N6O4
Molecular Weight
368.35
References & Citations
[1]Yangsook Song Green, et al. ISCA2 inhibition decreases HIF and induces ferroptosis in clear cell renal carcinoma. Oncogene. 2022 Sep 12.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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