PTP1B-IN-3 (diammonium)

PTP1B-IN-3 diammonium is a potent and orally active PTP1B inhibitor with IC50s of 120 nM for both PTP1B and TCPTP. PTP1B-IN-3 diammonium has antidiabetic and anticancer effects[1][2].

Product Specifications

CAS Number

[2702673-78-5]

UNSPSC

12352005

Target

Phosphatase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/ptp1b-in-3-diammonium.html

Purity

95.38

Solubility

10 mM in DMSO

Smiles

BrC1=C(C(F)(P(O)(O)=O)F)C=C2C(C=CC(C#N)=C2)=C1.N.N

Molecular Formula

C12H13BrF2N3O3P

Molecular Weight

396.12

References & Citations

[1]Price N, et al. Safety and Efficacy of a Topical Sodium Channel Inhibitor (TV-45070) in Patients With Postherpetic Neuralgia (PHN) : A Randomized, Controlled, Proof-of-Concept, Crossover Study, With a Subgroup Analysis of the Nav1.7 R1150W Genotype. Clin J Pain. 2017 Apr;33 (4) :310-318.|[2]Yongxin Han, et al. Discovery of [ (3-bromo-7-cyano-2-naphthyl) (difluoro) methyl]phosphonic acid, a potent and orally active small molecule PTP1B inhibitor. Bioorg Med Chem Lett. 2008 Jun 1;18 (11) :3200-5.