AChE-IN-25
AChE-IN-25 is a potent, selective and uncompetitive acetylcholinesterase (AChE) inhibitor (IC50=2.95 µM) . AChE-IN-25 can be used in Alzheimer's disease research[1].
Product Specifications
CAS Number
2835538-69-5
UNSPSC
12352005
Target
Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ache-in-25.html
Solubility
10 mM in DMSO
Smiles
O=C(N)C(C1=C(C2=CC=C(Cl)C=C2)N(C3=CC=C(O)C=C3)C(SC)=C1[N+]([O-])=O)C#N
Molecular Formula
C20H15ClN4O4S
Molecular Weight
442.88
References & Citations
[1]Hormoz Pourtaher, et al. Design, synthesis, in silico and biological evaluations of novel polysubstituted pyrroles as selective acetylcholinesterase inhibitors against Alzheimer's disease. Sci Rep. 2022 Sep 8;12 (1) :15236.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE
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