AChE-IN-25

AChE-IN-25 is a potent, selective and uncompetitive acetylcholinesterase (AChE) inhibitor (IC50=2.95 µM) . AChE-IN-25 can be used in Alzheimer's disease research[1].

Product Specifications

CAS Number

[2835538-69-5]

UNSPSC

12352005

Target

Cholinesterase (ChE)

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ache-in-25.html

Solubility

10 mM in DMSO

Smiles

O=C(N)C(C1=C(C2=CC=C(Cl)C=C2)N(C3=CC=C(O)C=C3)C(SC)=C1[N+]([O-])=O)C#N

Molecular Formula

C20H15ClN4O4S

Molecular Weight

442.88

References & Citations

[1]Hormoz Pourtaher, et al. Design, synthesis, in silico and biological evaluations of novel polysubstituted pyrroles as selective acetylcholinesterase inhibitors against Alzheimer's disease. Sci Rep. 2022 Sep 8;12 (1) :15236.