O-Phospho-L-serine-13C3,15N

O-Phospho-L-serine-13C3,15N is the 13C- and 15N-labeled O-Phospho-L-serine. O-Phospho-L-serine is the immediate precursor to L-serine in the serine synthesis pathway, and an agonist at the group III mGluR receptors (mGluR4, mGluR6, mGluR7, and mGluR8) ; O-Phospho-L-serine also acts as a weak antagonist for mGluR1 and a potent antagonist for mGluR2[1].

Product Specifications

CAS Number

[2734706-69-3]

Product Name Alternative

L-Serine O-phosphate-13C3,15N; L-SOP-13C3,15N

UNSPSC

12352211

Hazard Statement

H314

Target

Endogenous Metabolite; mGluR

Type

Isotope-Labeled Compounds

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/o-phospho-l-serine-13c3-15n.html

Purity

99.19

Solubility

H2O : 25 mg/mL (ultrasonic; warming)

Smiles

OP(O[13CH2][13C@H]([15NH2])[13C](O)=O)(O)=O

Molecular Formula

13C3H8 15NO6P

Molecular Weight

189.04

Precautions

H314

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Kang HJ, et al. Determinants of endogenous ligand specificity divergence among metabotropic glutamate receptors. J Biol Chem. 2015 Jan 30;290 (5) :2870-8.|[3]Kang HJ, et al. Selectivity and evolutionary divergence of metabotropic glutamate receptors for endogenous ligands and G proteins coupled to phospholipase C or TRP channels. J Biol Chem. 2014 Oct 24;289 (43) :29961-74.|[4]Bailey TJ, et al. The inhibitor of phagocytosis, O-phospho-L-serine, suppresses Müller glia proliferation and cone cell regeneration in the light-damaged zebrafish retina. Exp Eye Res. 2010 Nov;91 (5) :601-12.