KRAS inhibitor-20
KRAS inhibitor-20 is a small molecular inhibitor of KRasG12C, the oncogenic mutant. KRAS inhibitor-20 inhibits KRasG12C with the IC50 value [1].
Product Specifications
CAS Number
[2411786-32-6]
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kras-inhibitor-20.html
Solubility
10 mM in DMSO
Smiles
C[C@H]1CN(C(C=C)=O)CCN1C2=NC(OC[C@H]3N(CCC3)C)=NC4=C2C[C@@H](C)[C@H](C5=C(F)C(N)=CC(C)=C5C(F)(F)F)C4
Molecular Formula
C31H40F4N6O2
Molecular Weight
604.68
References & Citations
[1]Kargbo RB. Small-Molecule Inhibitor of the Oncogenic KRASG12C Mutant for the Treatment of Currently Incurable Cancer. ACS Med Chem Lett. 2022 Apr 20;13 (5) :767-769.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras
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