KRAS inhibitor-20

KRAS inhibitor-20 is a small molecular inhibitor of KRasG12C, the oncogenic mutant. KRAS inhibitor-20 inhibits KRasG12C with the IC50 value [1].

Product Specifications

CAS Number

[2411786-32-6]

UNSPSC

12352005

Target

Ras

Type

Reference compound

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/kras-inhibitor-20.html

Solubility

10 mM in DMSO

Smiles

C[C@H]1CN(C(C=C)=O)CCN1C2=NC(OC[C@H]3N(CCC3)C)=NC4=C2C[C@@H](C)[C@H](C5=C(F)C(N)=CC(C)=C5C(F)(F)F)C4

Molecular Formula

C31H40F4N6O2

Molecular Weight

604.68

References & Citations

[1]Kargbo RB. Small-Molecule Inhibitor of the Oncogenic KRASG12C Mutant for the Treatment of Currently Incurable Cancer. ACS Med Chem Lett. 2022 Apr 20;13 (5) :767-769.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

K-Ras

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