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ALK5-IN-25

ALK5-IN-25 (compound EX-02) is a potent ALK-5 inhibitor with an IC50 ≤10 nM.ALK5-IN-25 also inhibits ALK-2 (selectivity ALK2/ALK5≤10) . ALK5-IN-25 can be used for the research of cancer[1].

Product Specifications

CAS Number

2785430-81-9

UNSPSC

12352005

Target

TGF-β Receptor

Type

Reference compound

Related Pathways

TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/alk5-in-25.html

Solubility

10 mM in DMSO

Smiles

CC1=C(F)C=CC2=C(NC3=NC(NC4=CC=C(N5CCNCC5)C=C4)=NC=C3)C=NN=C12

Molecular Formula

C23H23FN8

Molecular Weight

430.48

References & Citations

[1]Bettina FRANZ, et al. Alk-5 inhibitors and uses thereof. Patent WO2022126133A1.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

ALK2; ALK5

Frequently Asked Questions

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