G4/HDAC-IN-1
G4/HDAC-IN-1 (compound a6) is a G4/HDAC dual-targeting compound. G4/HDAC-IN-1 inhibits intracellular HDAC activity with an IC50 value of 1.1 μM, and induces G4 formation. G4/HDAC-IN-1 inhibits TNBC proliferation and tumor growth in TNBC xenograft model. G4/HDAC-IN-1 can be used for the research of cancer[1].
Product Specifications
CAS Number
3031784-60-5
UNSPSC
12352005
Target
G-quadruplex; HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/g4-hdac-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C(NCCCN(C)C)C1=CC=C(/C=C2CCN3C\2=NC4=C(C=C(F)C(N5CCN(CCCCCCCC(NO)=O)CC5)=C4)C3=O)C=C1.Cl
Molecular Formula
C36H49ClFN7O4
Molecular Weight
698.27
References & Citations
[1]Jiang XC, et al. Discovery of a Novel G-Quadruplex and Histone Deacetylase (HDAC) Dual-Targeting Agent for the Treatment of Triple-Negative Breast Cancer. J Med Chem. 2022 Sep 2.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC11; HDAC4; HDAC6; HDAC8
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