AChE/BACE1/GSK3β-IN-1
AChE/BACE1/GSK3β-IN-1 is an orally active triple inhibitor of AChE/BACE1/GSK3β. AChE/BACE1/GSK3β-IN-1 has effective inhibitory activity against AChE, BACE1 and GSK3β with IC50 values of 1.0 μM, 20 μM and 15 μM, respectively. AChE/BACE1/GSK3β-IN-1 has good blood-brain barrier penetrability, suitable bioavailability. AChE/BACE1/GSK3β-IN-1 can be used for the research of Alzheimer's disease (AD) [1].
Product Specifications
CAS Number
2866066-81-9
UNSPSC
12352005
Target
Beta-secretase; Cholinesterase (ChE) ; GSK-3
Type
Reference compound
Related Pathways
Neuronal Signaling; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ache-bace1-gsk3β-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C1C=CC2=C(OCCCN3CCC(NCC4=CC(F)=CC=C4)CC3)C5=C(OC=C5)C=C2O1
Molecular Formula
C26H27FN2O4
Molecular Weight
450.50
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; BACE1; GSK-3β
Frequently Asked Questions
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