TK4g
TK4g is a Janus kinase (JAK) inhibitor with the IC50 values of 12.61 nM and 15.80 nM for JAK2 and JAK3, respectively. TK4g can be used in lymphoid-derived diseases and leukemia cancer research[1].
Product Specifications
CAS Number
2232890-86-5
UNSPSC
12352005
Target
JAK
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tk4g.html
Solubility
10 mM in DMSO
Smiles
O=S(C1=CC=CC(N2N(CC)C(C)=C(C(C3=CC=CC=C3)=O)C2=O)=C1)(N)=O
Molecular Formula
C19H19N3O4S
Molecular Weight
385.44
References & Citations
[1]Kamonpan Sanachai, et al. Pharmacophore-Based Virtual Screening and Experimental Validation of Pyrazolone-Derived Inhibitors toward Janus Kinases. ACS Omega 2022.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JAK2; JAK3
Frequently Asked Questions
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