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JAK-2/3-IN-2

JAK-2/3-IN-2 (Compound 3h) is a JAK2 and JAK3 inhibitor with IC50s of 23.85 nM and 18.9 nM, respectively[1].

Product Specifications

CAS Number

2170398-48-6

UNSPSC

12352005

Target

JAK

Type

Reference compound

Related Pathways

Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/jak-2-3-in-2.html

Solubility

10 mM in DMSO

Smiles

O=C1N(C2=CC=CC=C2Cl)N(CC)C(C)=C1SC3=CC=C(C)C=C3

Molecular Formula

C19H19ClN2OS

Molecular Weight

358.88

References & Citations

[1]Sanachai K, et al. Pharmacophore-Based Virtual Screening and Experimental Validation of Pyrazolone-Derived Inhibitors toward Janus Kinases. ACS Omega, 2022.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

JAK2; JAK3

Frequently Asked Questions

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