HIV-1 protease-IN-7

HIV-1 protease-IN-7 (compound 16) is an orally active HIV-1 protease inhibitor (IC50=3.52 nM, EC50=37 nM) [1].

Product Specifications

CAS Number

[2916441-36-4]

UNSPSC

12352209

Target

HIV Protease

Type

Peptides

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/hiv-1-protease-in-7.html

Solubility

10 mM in DMSO

Smiles

O=C1N[C@@H](CC(C)C)C(N[C@@H](CCC2CCCCC2)C(N[C@H](C(N([C@H](C(N[C@@H](C)C(N[C@H](C(OC)=O)C(C)(C)SCC(N[C@H](C(N[C@H](C(N3CCC[C@@](C(N[C@H]1C(C)C)=O)3C)=O)C(C)C)=O)CC4=CC=CC=C4)=O)=O)=O)CC5=CC=CC=C5)C)=O)CC(C)C)=O)=O

Molecular Formula

C68H104N10O12S

Molecular Weight

1285.68

References & Citations

[1]Kusumoto Y, et al. Highly Potent and Oral Macrocyclic Peptides as a HIV-1 Protease Inhibitor: mRNA Display-Derived Hit-to-Lead Optimization. ACS Medicinal Chemistry Letters, 2022.