BTK-IN-16

BTK-IN-16 is a dual inhibitor of BTK wild type and C481S mutant of Bruton’s tyrosine kinase (BTK) with IC50s of 5.1 and 4.1 μM. BTK-IN-16 can be used for the research of autoimmune diseases and chronic lymphocytic leukemia[1].

Product Specifications

CAS Number

[2883232-92-4]

UNSPSC

12352005

Target

Btk

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/btk-in-16.html

Solubility

10 mM in DMSO

Smiles

COC1=CC(C(C=C1OC)=NC=N2)=C2NC3=CC=CN=C3

Molecular Formula

C15H14N4O2

Molecular Weight

282.30

References & Citations

[1]Kim T, et al. Two-Track Virtual Screening Approach to Identify the Dual Inhibitors of Wild Type and C481S Mutant of Bruton's Tyrosine Kinase. J Chem Inf Model. 2022 Aug 24.