PKG1α activator 3
PKG1α activator 3 is a PKG1α activator (EC50 basal/partial=13/0.52 μM) . PKG1α activator 3 shows anti-proliferative effects to smooth muscle cell, and can be used in cardiovascular disease research[1].
Product Specifications
CAS Number
2773367-58-9
UNSPSC
12352005
Target
PKG
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/pkg1α-activator-3.html
Solubility
10 mM in DMSO
Smiles
O=C(O)C1=CC=C(CN2[C@@H](C3=CC=CC=C3)[C@@H](O[C@@H](C4=CC(Cl)=CC(Cl)=C4)CO)CCC2)C([N+]([O-])=O)=C1
Molecular Formula
C27H26Cl2N2O6
Molecular Weight
545.41
References & Citations
[1]Victor W Mak, et al. Optimization and Mechanistic Investigations of Novel Allosteric Activators of PKG1α. J Med Chem. 2022 Aug 11;65 (15) :10318-10340.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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