PKG1α activator 3

PKG1α activator 3 is a PKG1α activator (EC50 basal/partial=13/0.52 μM) . PKG1α activator 3 shows anti-proliferative effects to smooth muscle cell, and can be used in cardiovascular disease research[1].

Product Specifications

CAS Number

[2773367-58-9]

UNSPSC

12352005

Target

PKG

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/pkg1α-activator-3.html

Solubility

10 mM in DMSO

Smiles

O=C(O)C1=CC=C(CN2[C@@H](C3=CC=CC=C3)[C@@H](O[C@@H](C4=CC(Cl)=CC(Cl)=C4)CO)CCC2)C([N+]([O-])=O)=C1

Molecular Formula

C27H26Cl2N2O6

Molecular Weight

545.41

References & Citations

[1]Victor W Mak, et al. Optimization and Mechanistic Investigations of Novel Allosteric Activators of PKG1α. J Med Chem. 2022 Aug 11;65 (15) :10318-10340.