20S Proteasome-IN-4
20S Proteasome-IN-4 (Compound 7) is a brain-penetrant, parasite-selective, orally active 20S proteasome inhibitor with an IC50 of 6.3 nM against T. b. brucei 20S proteasome. 20S Proteasome-IN-4 can be used for the research of human African trypanosomiasis (HAT) [1].
Product Specifications
CAS Number
[2827061-47-0]
UNSPSC
12352005
Target
Parasite; Proteasome
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/20s-proteasome-in-4.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC=C2C(C(NC3=CC=CC(F)=C3F)=CC(C(NC[C@H](CO)OC)=O)=N2)=C1
Molecular Formula
C20H18ClF2N3O3
Molecular Weight
421.83
References & Citations
[1]Koester DC, et al. Discovery of Novel Quinoline-Based Proteasome Inhibitors for Human African Trypanosomiasis (HAT) . J Med Chem. 2022 Aug 22.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
Mouse Monoclonal TRIM29 Antibody (TRIM29/1042) [Alexa Fluor 700]
