Cis-4-Br-2,5-F2-PCPA
Cis-4-Br-2,5-F2-PCPA (S1024) is a selective inhibitor of lysine-specific demethylase 1 (LSD1), with a Ki value of 94 nM instead of 8.4 μM for LSD2. There is aberrant expression of LSD1 in cancer stem cells, cis-4-Br-2,5-F2-PCPA inhibits LSD1 cell proliferation and by increasing the level of dimethylated histone H3 at K4 (H3K4) in CCRF-CEM cells[1].
Product Specifications
CAS Number
2821068-03-3
Product Name Alternative
S1024
UNSPSC
12352005
Target
Histone Demethylase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cis-4-br-2-5-f2-pcpa.html
Solubility
10 mM in DMSO
Smiles
N[C@@H]1C[C@@H]1C2=C(F)C=C(Br)C(F)=C2
Molecular Formula
C9H8BrF2N
Molecular Weight
248.07
References & Citations
[1]Hideaki Niwa, et al. Structure–Activity Relationship and In Silico Evaluation of cis- and trans-PCPA-Derived Inhibitors of LSD1 and LSD2. ACS Med. Chem. Lett. 2022.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
KDM1/LSD1
Frequently Asked Questions
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