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Sirt2-IN-7

Sirt2-IN-7 (compound 22) is a selective inhibitor of SIRT2. Sirt2-IN-7 inhibits SIRT2 with an IC50 value and a Ki value of 178.2 nM and 154.3 nM, respectively. Sirt2-IN-7 can be used for the research of cancer[1].

Product Specifications

UNSPSC

12352005

Target

Sirtuin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sirt2-in-7.html

Solubility

10 mM in DMSO

Smiles

CCCCCCCCCCCCC[C@H](SC1=CC=C(C(Cl)=C1)Cl)CC(N[Ac-KKT-NH2])=O

Molecular Formula

C40H68Cl2N6O6S

Molecular Weight

831.98

References & Citations

[1]Kalbas D, et al. Small Changes Make the Difference for SIRT2: Two Different Binding Modes for 3-Arylmercapto-Acylated Lysine Derivatives. Biochemistry. 2022 Aug 16. doi: 10.1021/acs.biochem.2c00211. Epub ahead of print. PMID: 35972884.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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