MDM2/4-p53-IN-1
Product Specifications
UNSPSC Description
MDM2/4-p53-IN-1 is a potent MDM2-p53 and MDM4-p53 inhibitor with IC50 values of 35.9, 57.4 nM, respectively. MDM2/4-p53-IN-1 shows antiproliferative activity[1].
Target Antigen
MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mdm2-4-p53-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C1NC2=CC(Cl)=CC=C2[C@@]13N(N=C(C(NC4=CC(N5N=CC=C5)=CC=C4)=O)[C@@H]3C6=CC(O)=CC=C6)C7=CC=C(C=C7)Cl
Molecular Weight
609.46
References & Citations
[1]Espadinha M, et al. Discovery of MDM2-p53 and MDM4-p53 protein-protein interactions small molecule dual inhibitors. Eur J Med Chem. 2022 Aug 5;241:114637.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-151169/MDM2-4-p53-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-151169/
Clinical Information
No Development Reported
CAS Number
3037300-57-2
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