HER2-IN-12
HER2-IN-12 is a HER2 inhibitor (IC50: 121 nM) . HER2-IN-12 can be used in the research of cancers, such as breast cancer[1].
Product Specifications
CAS Number
[2820126-51-8]
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/her2-in-12.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CSC2=NC(CN3CCOCC3)=C(C4=CC=C(Br)C=C4)N21)NN
Molecular Formula
C17H18BrN5O2S
Molecular Weight
436.33
References & Citations
[1]Mohamed A Sabry, et al. New thiazole-based derivatives as EGFR/HER2 and DHFR inhibitors: Synthesis, molecular modeling simulations and anticancer activity. Eur J Med Chem. 2022 Aug 10;241:114661.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ErbB2/HER2
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