LasR-IN-1
LasR-IN-1 (compound 9g) is a potent LasR inhibitor. LasR-IN-1 has good efficacy toward E. coli. LasR-IN-1 shows anti-bacterial activity, with a MIC of 28.13 μM against P. aeruginosa[1].
Product Specifications
CAS Number
3033530-75-2
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/lasr-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=C(C)C=C1)COC2=CC=C(C3=NC4=CC(C)=CC=C4N3)C=C2
Molecular Formula
C23H21N3O2
Molecular Weight
371.43
References & Citations
[1]Abd El-Aleam RH, et al. Design and synthesis of novel benzimidazole derivatives as potential Pseudomonas aeruginosa anti-biofilm agents inhibiting LasR: Evidence from comprehensive molecular dynamics simulation and in vitro investigation. Eur J Med Chem. 2022 Aug 5;241:114629.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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