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LasR-IN-1

LasR-IN-1 (compound 9g) is a potent LasR inhibitor. LasR-IN-1 has good efficacy toward E. coli. LasR-IN-1 shows anti-bacterial activity, with a MIC of 28.13 μM against P. aeruginosa[1].

Product Specifications

CAS Number

[3033530-75-2]

UNSPSC

12352005

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/lasr-in-1.html

Solubility

10 mM in DMSO

Smiles

O=C(NC1=CC=C(C)C=C1)COC2=CC=C(C3=NC4=CC(C)=CC=C4N3)C=C2

Molecular Formula

C23H21N3O2

Molecular Weight

371.43

References & Citations

[1]Abd El-Aleam RH, et al. Design and synthesis of novel benzimidazole derivatives as potential Pseudomonas aeruginosa anti-biofilm agents inhibiting LasR: Evidence from comprehensive molecular dynamics simulation and in vitro investigation. Eur J Med Chem. 2022 Aug 5;241:114629.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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