Trypanothione synthetase-IN-4
Trypanothione synthetase-IN-4 is a L. infantum trypanothione synthetase (TryS) inhibitor, and the activity is dependent on the concentration of the polyamine substrate. Trypanothione synthetase-IN-4 has potent antileishmanicidal activity with an EC50 value of 0.6 μM and a selectivity index of 35. Trypanothione synthetase-IN-4 can be used for the research of leishmaniasis[1].
Product Specifications
UNSPSC
12352005
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/trypanothione-synthetase-in-4.html
Solubility
10 mM in DMSO
Smiles
C[N+](C)(CC1=CC(OC)=C(C=C1)OCCCCCCCCCCCCCC)C2CCCC2.[I-]
Molecular Formula
C29H52INO2
Molecular Weight
573.63
References & Citations
[1]M. Alcón-Calderón, et al. Identification of L. infantum trypanothione synthetase inhibitors with leishmanicidal activity from a (non-biased) in-house chemical library, European Journal of Medicinal Chemistry (2022) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Leishmania
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