Trypanothione synthetase-IN-1

Trypanothione synthetase-IN-1 (Compound 1) is a competitive Leishmania infantum trypanothione synthetase (TryS) inhibitor with an IC50 of 14.8 μM when triamine spermidine is as polyamine S[1].

Product Specifications

CAS Number

[2355349-41-4]

UNSPSC

12352005

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/trypanothione-synthetase-in-1.html

Solubility

10 mM in DMSO

Smiles

[NH3+]CCCCC1=CN(C2=CC(OCCN3CCNC3=O)=C(C=C2)C4=NC(C5=CC=C(C=C5)OC6=CC=CC=C6)=C(C7=CC=CC=C7)S4)N=N1.O=C([O-])C(F)(F)F

Molecular Formula

C40H38F3N7O5S

Molecular Weight

785.83

References & Citations

[1]Alcón-Calderón M, et al. Identification of L. infantum trypanothione synthetase inhibitors with leishmanicidal activity from a (non-biased) in-house chemical library. European Journal of Medicinal Chemistry, 2022: 114675.