HSP90/mTOR-IN-1

HSP90/mTOR-IN-1 is a potent and orally active Hsp90 and mTOR inhibitor with IC50 values of 69 nM and 29 nM, respectively. HSP90/mTOR-IN-1 suppresses the proliferation of SW780 cells through the over-activation of the PI3K/AKT/mTOR pathway. HSP90/mTOR-IN-1 induces apoptosis and autophagy via selective Hsp90 and mTOR inhibition. HSP90/mTOR-IN-1 also has considerable in vivo anti-tumor activity. HSP90/mTOR-IN-1 can be used for researching bladder cancer[1].

Product Specifications

CAS Number

[3033543-67-5]

UNSPSC

12352005

Target

Apoptosis; Autophagy; HSP; mTOR

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hsp90-mtor-in-1.html

Solubility

10 mM in DMSO

Smiles

ClC1=CC(NC(NC2=CC=C(C=C2)C3=NC(N4CCOCC4)=C5C6=C(SC5=N3)CN(CC6)C(C7=CC(C(C)C)=C(C=C7O)O)=O)=O)=CC=C1F

Molecular Formula

C36H34ClFN6O5S

Molecular Weight

717.21

References & Citations

[1]Pan Z, et al. Design, synthesis, and biological evaluation of novel dual inhibitors of heat shock protein 90/mammalian target of rapamycin (Hsp90/mTOR) against bladder cancer cells. Eur J Med Chem. 2022 Aug 13;242:114674.