HBV-IN-25
HBV-IN-25 is a good potency, orally active novel HBV cccDNA reducer. HBV-IN-25 has anti-HBeAg potency and anti-HBV activity with IC50 values of 0.58 μM and 1.15 μM, respectively. HBV-IN-25 has good aqueous solubility (LYSA > 452 μg/mL) and good PK property with no cellular toxicity[1].
Product Specifications
CAS Number
2161364-69-6
UNSPSC
12352005
Target
HBV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/hbv-in-25.html
Solubility
10 mM in DMSO
Smiles
O=C([C@H]1CN(C2=CC(OC3=C4C=CC=C3Cl)=C(C=C2)C4=O)CC1)O
Molecular Formula
C18H14ClNO4
Molecular Weight
343.76
References & Citations
[1]Dongdong Chen, et al. Discovery of Novel cccDNA Reducers toward the Cure of Hepatitis B Virus Infection. J Med Chem. 2022 Aug 16.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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