JTP-4819
JTP-4819 is a potent and specific inhibitor of prolyl endopeptidase (PREP) with IC50s of 0.83 nM (in rat brain supernatant) and 5.43 nM (in Flavobacterium meningosepticum). JTP-4819 has blood-brain penetration, also improves the retention time of amnesia rats induced by Scopolamine[2].
Product Specifications
CAS Number
162203-65-8
UNSPSC
12352005
Target
Prolyl Endopeptidase (PREP)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/jtp-4819.html
Solubility
10 mM in DMSO
Smiles
O=C(N1[C@H](C(N2[C@H](C(CO)=O)CCC2)=O)CCC1)NCC3=CC=CC=C3
Molecular Formula
C19H25N3O4
Molecular Weight
359.42
References & Citations
[1]Toide K, et al. JTP-4819: a novel prolyl endopeptidase inhibitor with potential as a cognitive enhancer. J Pharmacol Exp Ther. 1995 Sep;274 (3) :1370-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
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