SB-423557
Product Specifications
UNSPSC Description
SB-423557 is an orally active calcium-sensing receptor (CaR) antagonist (IC50=520 nM), precursor of SB-423562 (IC50=73 nM). SB-423557 is well tolerated in human and increases plasma concentrations of exogenous parathyroid hormone (PTH) and stimulates bone formation[1].
Target Antigen
CaSR
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sb-423557.html
Solubility
10 mM in DMSO
Smiles
O=C(OCC)CCC1=CC=C(C#N)C(OC[C@H](O)CNC(C)(C)CC2CC3=C(C=CC=C3)C2)=C1
Molecular Weight
464.60
References & Citations
[1]Kumar S, et al. An orally active calcium-sensing receptor antagonist that transiently increases plasma concentrations of PTH and stimulates bone formation. Bone. 2010 Feb;46(2):534-42.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-15106/SB-423557-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-15106/
Clinical Information
No Development Reported
CAS Number
351490-26-1
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