SB-423557

SB-423557 is an orally active calcium-sensing receptor (CaR) antagonist (IC50=520 nM), precursor of SB-423562 (IC50=73 nM) . SB-423557 is well tolerated in human and increases plasma concentrations of exogenous parathyroid hormone (PTH) and stimulates bone formation[1].

Product Specifications

CAS Number

[351490-26-1]

UNSPSC

12352005

Target

CaSR

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/sb-423557.html

Solubility

10 mM in DMSO

Smiles

O=C(OCC)CCC1=CC=C(C#N)C(OC[C@H](O)CNC(C)(C)CC2CC3=C(C=CC=C3)C2)=C1

Molecular Formula

C28H36N2O4

Molecular Weight

464.60

References & Citations

[1]Kumar S, et al. An orally active calcium-sensing receptor antagonist that transiently increases plasma concentrations of PTH and stimulates bone formation. Bone. 2010 Feb;46 (2) :534-42.