ICy-Q
ICy-Q is a quinone oxidoreductase 1 (NQO-1) -activated near-infrared (NIR) reagent which can react with NQO-1 to release the reduction product ICy-OH. ICy-OH selectively induces pancreatic cancer cell death through the pyroptosis pathway. ICy-Q can be used as an effective tool for rapid and accurate diagnosis of intraoperative pathological sections[1].
Product Specifications
CAS Number
2863682-83-9
UNSPSC
12352005
Target
Pyroptosis
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/icy-q.html
Solubility
10 mM in DMSO
Smiles
CC1=C(C(C(C(C)(C)CC(N(C2=CC=C(C=C2)COC3=CC4=C(C=C5CCCC(/C=C/C6=[N+](C7=C(C6(C)C)C=C(C=C7)I)C)=C5O4)C=C3)C)=O)=C(C1=O)C)=O)C.[I-]
Molecular Formula
C48H50I2N2O5
Molecular Weight
988.73
References & Citations
[1]Bo Peng, et al. NQO-1 Enzyme-Activated NIR Theranostic Agent for Pancreatic Cancer. Anal Chem. 2022 Aug 2.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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